Asian Journal of Research in Chemistry

Hemant Badwaik ¹, S. Venkataraman ², Deepa Thakur ¹, Minu Vinod ¹, J. Raamamurthy ¹, Kiran Deshmukh ²

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN
2 K.M. College of Pharmacy, Madurai (T.N), IN

Abstract

Acetanilide was cyclized via Vilsmeier-Haack reagent to give 2- chloro -3- formyl quinoline. The aldehydic group was protected to prevent the preferential attack of nitrogen nucleophiles. The protection of aldehydic group in the present system was achieved with ethylene glycol to afford dioxolan derivative. Dioxolan derivative treated with nitro substituted phenyl hydrazine in alcoholic solution followed by deprotection of aldehydic group afforded the 2-(2-(2- nitrophenyl) hydrazinyl) quinoline-3-carbaldehyde and 2-(2-(2, 4-dinitrophenyl) hydrazinyl) quinoline-3- carbaldehyde. The synthesized derivatives were screened for antimicrobial activity.

Keywords

Vilsmeier–Haack Reagent, Dioxolan, 2-(2-(2, 4-Dinitrophenyl) Hydrazinyl) Quinoline-3- Carbaldehyde, Antimicrobial Agent.

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R. Xavier Arulappa ¹, M. Sundarapandian ², Rithesh Singh ¹, S. Venkataraman ¹

Affiliations
1 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-107, IN
2 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-107, IN

Abstract

A simple, precise and accurate spectrophotometric method has been developed for the determination of Quetiapine fumarate in bulk drug and pharmaceutical dosage form. Standard stock solution was prepared in distilled water and further dilution was carried out with distilled water. The λmax of Quetiapine fumarate was found to be 290 nm. The A (1%,1 cm) value of Quetiapine fumarate was found to be 186.22±3.11. Calibration graph was linear over the range of 5-25 μg/ml. The correlation coefficient (r) was found to be 0.9997. The limit of detection (LOD) and limit of Quantification (LOQ) was found to be 0.41 μg/ml and 1.25 μg/ml respectively of Quetiapine fumarate. The result of estimation in marketed tablet formulations were found to be 100.64±0.18 and 101.32±0.35. The proposed method was applied successfully for the determination of Quetiapine fumarate in tablets with average recovery of 102±1.14 and 98.8±1.10. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.

Keywords

Quetiapine Fumarate, Spectrophotometry.

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M. Sundarapandian ¹, S. Venkataraman ², R. Xavierarulappa ², M. Boopathi ¹, S. Selvakumar ²

Affiliations
1 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN
2 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN

Abstract

A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Meloxicam has been developed based on the formation of ion-pair of Meloxicam with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415 nm. Beer’s law limit was found to be 10-50 mcg/ml. The molar absorptivity was found to be 2.17×10³ (mole^-1cm^-1) and sandell’s sensitivity was 0.1612 (μg/cm²/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.88 and 2.69 mcg/ml respectively of Meloxicam. The result of estimation in marketed formulations was found to be 99.86±0.32 and 97.93±0.32. The proposed method was applied successfully for the determination of Meloxicam in tablets with average recovery of 99.62±0.88 and 100.4±0.768. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.

Keywords

Meloxicam, Bromo Cresol Green, Spectrophotometry.

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